EPCAM APTAMER-FUNCTIONALIZED POLYDOPAMINE-COATED MESOPOROUS SILICA NANOPARTICLES LOADED WITH DM1 FOR TARGETED THERAPY IN COLORECTAL CANCER

EpCAM aptamer-functionalized polydopamine-coated mesoporous silica nanoparticles loaded with DM1 for targeted therapy in colorectal cancer

Yang Li,1,* Yanhong Duo,2,3,* Shiyun Bao,1 fr3622 Lisheng He,4 Kai Ling,5 Jinfeng Luo,4 Yue Zhang,1 Hao Huang,2 Han Zhang,2 Xiaofang Yu1 1Department of Hepatobiliary and Pancreas Surgery, Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, 2Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, Collab

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Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay

Abstract Chronic wasting disease (CWD) is a fatal prion disease which infects deer, elk and moose.CWD was first described as a wasting syndrome in captive deer in Colorado and Wyoming wildlife facilities from 1967 to 1979.Currently, CWD has been mg09aca18te reported in 26 states of the USA, three Canadian provinces, South Korea, Norway and Finland.

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Loneliness in the UK during the COVID-19 pandemic: Cross-sectional results from the COVID-19 Psychological Wellbeing Study.

ObjectivesLoneliness is a significant public health issue.The COVID-19 alpha phi blanket pandemic has resulted in lockdown measures limiting social contact.The UK public are worried about the impact of these measures on mental health outcomes.Understanding the prevalence and predictors of loneliness at this time is a priority issue for research.Met

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